Calm Plex
$32.95
What This Product Does
- Helps lower stress hormones naturally so you feel more calm and relaxed*
- Supports better sleep and mental clarity without sedation*
- Improves your ability to handle daily stress and anxiety*
How to Use
Take 1 capsule twice daily with meals.
Key Ingredients
Full Ingredients: Withania somnifera (Ashwagandha), Bacopa monnieri (Brahmi), Nardostachys jatamansi (Jatamansi), Convolvulus pluricaulis (Shankhpushpi)
Ayurvedic Energetics
| Rasa (Taste) | Tikta (Bitter), Kashaya (Astringent), Madhura (Sweet) |
| Virya (Potency) | Sheeta (Cooling) — net cooling due to Brahmi/Jatamansi predominance |
| Vipaka (Post-digestive) | Madhura (Sweet) |
| Dosha Action | Tridoshic; primarily pacifies Vata and Pitta |
Science & Research
A synergistic adaptogenic formula combining four evidence-based botanicals targeting the hypothalamic-pituitary-adrenal (HPA) axis and GABAergic neurotransmission. Ashwagandha's withanolides demonstrate dose-dependent serum cortisol reduction (up to 30% in RCTs) and GABAergic anxiolytic activity. Bacopa monnieri's bacosides enhance synaptic kinase activity and serotonin modulation, with 12-week RCTs showing statistically significant improvements in working memory, attention, and cognitive processing speed. Jatamansi sesquiterpenes exhibit GABA-transaminase inhibition providing non-sedating anxiolytic action. Shankhpushpi contributes additional nootropic and thyroid-modulating properties.
Clinical Key Functions
- GABA-transaminase inhibition from Jatamansi sesquiterpenes*
- Serotonin receptor modulation supporting mood stability*
- Neuroprotective antioxidant activity in hippocampal neurons*
Selected Research
- Chandrasekhar K, et al. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of Ashwagandha root in reducing stress and anxiety. Indian J Psychol Med. 2012;34(3):255-262.
- Calabrese C, et al. Effects of a Standardized Bacopa monnieri Extract on Cognitive Performance, Anxiety, and Depression in the Elderly. J Altern Complement Med. 2008;14(6):707-713.
- Salim S, et al. Nardostachys jatamansi DC and Valeriana jatamansi DC: Therapeutic perspectives. J Ethnopharmacol. 2003;85(1):105-108.
- Sethiya NK, et al. An update on Shankhpushpi, a cognition-boosting Ayurvedic medicine. Zhong Xi Yi Jie He Xue Bao. 2009;7(11):1001-1022.
Ayurvedic Philosophy
This formulation unites all four Medhya Rasayanas described in the Charaka Samhita — the most important cognitive rejuvenative herbs in Ayurveda. The concept of Medhya Rasayana addresses the junction of Manas (mind) and Sharira (body), recognizing that mental disturbance (Manasika Roga) arises from the vitiation of Prana Vata (governing mental activity), Sadhaka Pitta (governing intellect and emotions), and Tarpaka Kapha (governing cerebral stability). The treatment strategy combines Medhya (cognitive), Nidrajanana (sleep-promoting), and Sattvavajaya (mind-strengthening) actions. Ashwagandha provides Balya Rasayana for Majja Dhatu (nervous tissue), Brahmi addresses Sadhaka Pitta, Jatamansi calms Prana Vata, and Shankhpushpi stabilizes Manovaha Srotas (mental channels).
Classical Text References
- Charaka Samhita, Chikitsa Sthana, Chapter 1 (Rasayana Adhyaya), Pada 3 — enumeration of the four premier Medhya Rasayanas: Mandukaparni, Yashtimadhu, Guduchi, and Shankhpushpi
- Charaka Samhita, Sutra Sthana, Chapter 1 (Deerghajivitiya Adhyaya) — principles of Sattvavajaya Chikitsa (psycho-rational therapy)
- Ashtanga Hridayam, Uttara Tantra, Chapter 6 (Unmada Chikitsa) — treatment of mental disorders through Medhya and Manasa-balya herbs