Guggulu
$59.95
What This Product Does
- Helps maintain healthy cholesterol and blood lipid levels*
- Supports thyroid function and metabolic health*
- Reduces inflammation throughout your body and joints*
How to Use
Take 1–2 capsules twice daily with warm water.
Key Ingredients
Full Ingredients: Commiphora mukul extract (Resin)
Ayurvedic Energetics
| Rasa (Taste) | Tikta (Bitter), Katu (Pungent), Kashaya (Astringent) |
| Virya (Potency) | Ushna (Heating) |
| Vipaka (Post-digestive) | Katu (Pungent) |
| Dosha Action | Pacifies Vata and Kapha; may increase Pitta |
Science & Research
Purified Commiphora mukul oleo-gum resin (Shuddha Guggulu) prepared via classical shodhana protocol to remove cytotoxic ketosteroids while preserving therapeutic guggulsterones (Z and E isomers). Guggulsterones function as promiscuous nuclear receptor modulators: FXR antagonism increases hepatic LDL receptor expression, PXR activation enhances drug/toxin metabolism, and thyroid-stimulating activity may enhance T4-to-T3 conversion via hepatic deiodinase upregulation. Anti-inflammatory effects occur through inhibition of NF-κB nuclear translocation and STAT3 phosphorylation. This represents one of Ayurveda's most extensively pharmacologically characterized botanicals with over 1,000 published studies.
Clinical Key Functions
- STAT3 phosphorylation blockade in inflammatory cascades*
- PXR-mediated phase I/II detoxification enzyme induction*
- Lipid peroxide scavenging and arterial plaque stabilization*
Selected Research
- Shishodia S, et al. Guggulsterone inhibits NF-κB and IκBα kinase activation. J Biol Chem. 2004;279(45):47148-47158.
- Urizar NL, Moore DD. GUGULIPID: a natural cholesterol-lowering agent. Annu Rev Nutr. 2003;23:303-313.
- Panda S, Kar A. Guggulu (Commiphora mukul) potentially ameliorates hypothyroidism in female mice. Pharmacol Res. 2005;52(6):487-493.
- Sarup P, et al. Pharmacology and Phytochemistry of Oleo-Gum Resin of Commiphora mukul. Scientifica. 2015;2015:138039.
Ayurvedic Philosophy
Guggulu (Commiphora mukul) is the only Dravya (substance) in Ayurveda that lends its name to an entire class of formulations — the Guggulu Kalpas. The Sushruta Samhita describes Guggulu's Shodhana (purification) in extensive detail, emphasizing that raw Guggulu must be processed with specific herbal decoctions (Triphala Kwatha, Vasaka Kwatha, or milk) to remove toxic ketosteroids while preserving therapeutic guggulsterones. Classified simultaneously as Lekhana (scraping), Medohara (fat-reducing), Vatahara (Vata-pacifying), and Rasayana (rejuvenative), Guggulu occupies a unique position in Dravyaguna Vijnana — it is one of the few heating, pungent substances that is also considered a Rasayana. The Yogaratnakara declares that no Vata disorder is beyond Guggulu's therapeutic reach.
Classical Text References
- Sushruta Samhita, Chikitsa Sthana, Chapter 5 (Mahavatayadhi Chikitsa) — detailed description of Guggulu Shodhana and its therapeutic applications in Vata disorders
- Sharangdhara Samhita, Madhyama Khanda, Chapter 7 — formulation principles for Guggulu Kalpas (Guggulu-based compound preparations)
- Charaka Samhita, Sutra Sthana, Chapter 25 (Yajjahpurushiya Adhyaya) — Guggulu among premier Lekhana and Medohara substances