{"product_id":"guggulu","title":"Guggulu","description":"\u003cdiv class=\"product-overview\"\u003e\n\u003ch3\u003eWhat This Product Does\u003c\/h3\u003e\n\u003cul class=\"benefits-list\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eHelps maintain healthy cholesterol and blood lipid levels\u003c\/strong\u003e*\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSupports thyroid function and metabolic health\u003c\/strong\u003e*\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReduces inflammation throughout your body and joints\u003c\/strong\u003e*\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003c\/div\u003e\u003cdiv class=\"product-usage\"\u003e\n\u003ch3\u003eHow to Use\u003c\/h3\u003e\n\u003cp\u003eTake 1–2 capsules twice daily with warm water.\u003c\/p\u003e\n\u003c\/div\u003e\u003ch3\u003eKey Ingredients\u003c\/h3\u003e\u003cdiv class=\"ingredient-highlights\"\u003e\u003cdiv class=\"ingredient-card\"\u003e\u003ca href=\"\/pages\/ingredient-guggulu\" class=\"ingredient-link\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0763\/3767\/6476\/t\/5\/assets\/guggulu.jpg?v=1774876505\" alt=\"Guggulu \/ Indian Bdellium\" class=\"ingredient-img\" onerror=\"this.style.display='none'\"\u003e\u003cspan class=\"ingredient-name\"\u003eGuggulu \/ Indian Bdellium\u003c\/span\u003e\u003cspan class=\"ingredient-botanical\"\u003e\u003cem\u003eCommiphora mukul\u003c\/em\u003e\u003c\/span\u003e\u003c\/a\u003e\u003c\/div\u003e\u003c\/div\u003e\u003cp\u003e\u003cstrong\u003eFull Ingredients:\u003c\/strong\u003e Commiphora mukul extract (Resin)\u003c\/p\u003e\u003cdetails class=\"product-section\"\u003e\u003csummary\u003e\u003ch3\u003eAyurvedic Energetics\u003c\/h3\u003e\u003c\/summary\u003e\u003ctable class=\"energetics-table\"\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eRasa (Taste)\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eTikta (Bitter), Katu (Pungent), Kashaya (Astringent)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eVirya (Potency)\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eUshna (Heating)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eVipaka (Post-digestive)\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eKatu (Pungent)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eDosha Action\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003ePacifies Vata and Kapha; may increase Pitta\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\u003c\/details\u003e\u003cdetails class=\"product-section\"\u003e\u003csummary\u003e\u003ch3\u003eScience \u0026amp; Research\u003c\/h3\u003e\u003c\/summary\u003e\u003cp\u003ePurified Commiphora mukul oleo-gum resin (Shuddha Guggulu) prepared via classical shodhana protocol to remove cytotoxic ketosteroids while preserving therapeutic guggulsterones (Z and E isomers). Guggulsterones function as promiscuous nuclear receptor modulators: FXR antagonism increases hepatic LDL receptor expression, PXR activation enhances drug\/toxin metabolism, and thyroid-stimulating activity may enhance T4-to-T3 conversion via hepatic deiodinase upregulation. Anti-inflammatory effects occur through inhibition of NF-κB nuclear translocation and STAT3 phosphorylation. This represents one of Ayurveda's most extensively pharmacologically characterized botanicals with over 1,000 published studies.\u003c\/p\u003e\n\u003ch4\u003eClinical Key Functions\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003eSTAT3 phosphorylation blockade in inflammatory cascades*\u003c\/li\u003e\n\u003cli\u003ePXR-mediated phase I\/II detoxification enzyme induction*\u003c\/li\u003e\n\u003cli\u003eLipid peroxide scavenging and arterial plaque stabilization*\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch4\u003eSelected Research\u003c\/h4\u003e\n\u003col class=\"research-refs\"\u003e\n\u003cli\u003e\u003cem\u003eShishodia S, et al. Guggulsterone inhibits NF-κB and IκBα kinase activation. J Biol Chem. 2004;279(45):47148-47158.\u003c\/em\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cem\u003eUrizar NL, Moore DD. GUGULIPID: a natural cholesterol-lowering agent. Annu Rev Nutr. 2003;23:303-313.\u003c\/em\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cem\u003ePanda S, Kar A. Guggulu (Commiphora mukul) potentially ameliorates hypothyroidism in female mice. Pharmacol Res. 2005;52(6):487-493.\u003c\/em\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cem\u003eSarup P, et al. Pharmacology and Phytochemistry of Oleo-Gum Resin of Commiphora mukul. Scientifica. 2015;2015:138039.\u003c\/em\u003e\u003c\/li\u003e\n\u003c\/ol\u003e\u003c\/details\u003e\u003cdetails class=\"product-section\"\u003e\u003csummary\u003e\u003ch3\u003eAyurvedic Philosophy\u003c\/h3\u003e\u003c\/summary\u003e\u003cp\u003eGuggulu (Commiphora mukul) is the only Dravya (substance) in Ayurveda that lends its name to an entire class of formulations — the Guggulu Kalpas. The Sushruta Samhita describes Guggulu's Shodhana (purification) in extensive detail, emphasizing that raw Guggulu must be processed with specific herbal decoctions (Triphala Kwatha, Vasaka Kwatha, or milk) to remove toxic ketosteroids while preserving therapeutic guggulsterones. Classified simultaneously as Lekhana (scraping), Medohara (fat-reducing), Vatahara (Vata-pacifying), and Rasayana (rejuvenative), Guggulu occupies a unique position in Dravyaguna Vijnana — it is one of the few heating, pungent substances that is also considered a Rasayana. The Yogaratnakara declares that no Vata disorder is beyond Guggulu's therapeutic reach.\u003c\/p\u003e\n\u003ch4\u003eClassical Text References\u003c\/h4\u003e\n\u003col\u003e\n\u003cli\u003e\u003cem\u003eSushruta Samhita, Chikitsa Sthana, Chapter 5 (Mahavatayadhi Chikitsa) — detailed description of Guggulu Shodhana and its therapeutic applications in Vata disorders\u003c\/em\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cem\u003eSharangdhara Samhita, Madhyama Khanda, Chapter 7 — formulation principles for Guggulu Kalpas (Guggulu-based compound preparations)\u003c\/em\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cem\u003eCharaka Samhita, Sutra Sthana, Chapter 25 (Yajjahpurushiya Adhyaya) — Guggulu among premier Lekhana and Medohara substances\u003c\/em\u003e\u003c\/li\u003e\n\u003c\/ol\u003e\u003c\/details\u003e","brand":"Sri Sai Nutrients","offers":[{"title":"90 Capsules","offer_id":46118107480252,"sku":"SSN-GUGGULU","price":59.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0763\/3767\/6476\/files\/Guggulu.jpg?v=1774737138","url":"https:\/\/srisainutrients.com\/products\/guggulu","provider":"Sri Sai Nutrients","version":"1.0","type":"link"}